Feeling in Covid time

[EN] In this work, a Learning-Service project that consists of working on somatosensory and special senses stimulation in people with intellectual and/or developmental disabilities is shown. This experience has been made through small and simple exercises, games or activities that allow these people to experience new sensations. In this activity, the participants have been students of Pharmacy and Education Degree and children of a special education school. The main aim is to develop the sensory and physical faculties and promoted the functionality of the person. University students had to encourage the students of special school to use their senses. For this task Pharmacy students had the help and advice of Education students. The sanitary situation obligates to develop this activity with a video calls. For both groups of students, this experience has been a different mechanism to learn and practice using a new way of communication. All Pharmacy degree students think that this experience is has been good for their future professional activity. The teachers from the Special Education Center indicated that these initiatives are very important for their collective.Ribate, MP.; Sangüesa, E.; Giner, B.; Lomba, L.; Llanas, C.; García, CB. (2021). Feeling in Covid time. En 7th International Conference on Higher Education Advances (HEAd'21). Editorial Universitat Politècnica de València. 307-315. https://doi.org/10.4995/HEAd21.2021.13118OCS30731

Edge Detection by Adaptive Splitting II. The Three-Dimensional Case

In Llanas and Lantarón, J. Sci. Comput. 46, 485–518 (2011) we proposed an algorithm (EDAS-d) to approximate the jump discontinuity set of functions defined on subsets of ℝ d . This procedure is based on adaptive splitting of the domain of the function guided by the value of an average integral. The above study was limited to the 1D and 2D versions of the algorithm. In this paper we address the three-dimensional problem. We prove an integral inequality (in the case d=3) which constitutes the basis of EDAS-3. We have performed detailed computational experiments demonstrating effective edge detection in 3D function models with different interface topologies. EDAS-1 and EDAS-2 appealing properties are extensible to the 3D cas

Stem Cell Res

Primary hyperoxaluria type 1 (PH1) is a rare autosomal recessive disorder of the liver metabolism due to functional deficiency of the peroxisomal enzyme alanine:glyoxylate aminotransferase (AGT). AGT deficiency results in overproduction of oxalate which complexes with calcium to form insoluble calcium-oxalate salts in urinary tracts, ultimately leading to end-stage renal disease. Currently, the only curative treatment for PH1 is combined liver-kidney transplantation, which is limited by donor organ shortage and lifelong requirement for immunosuppression. Transplantation of genetically modified autologous hepatocytes is an attractive therapeutic option for PH1. However, the use of fresh primary hepatocytes suffers from limitations such as organ availability, insufficient cell proliferation, loss of function, and the risk of immune rejection. We developed patient-specific induced pluripotent stem cells (PH1-iPSCs) free of reprogramming factors as a source of renewable and genetically defined autologous PH1-hepatocytes. We then investigated additive gene therapy using a lentiviral vector encoding wild-type AGT under the control of the liver-specific transthyretin promoter. Genetically modified PH1-iPSCs successfully provided hepatocyte-like cells (HLCs) that exhibited significant AGT expression at both RNA and protein levels after liver-specific differentiation process. These results pave the way for cell-based therapy of PH1 by transplantation of genetically modified autologous HLCs derived from patient-specific iPSCs

Maternal iron kinetics and maternal–fetal iron transfer in normal-weight and overweight pregnancy

Background Inflammation during pregnancy may aggravate iron deficiency (ID) by increasing serum hepcidin and reducing iron absorption. This could restrict iron transfer to the fetus, increasing risk of infant ID and its adverse effects. Objectives We aimed to assess whether iron bioavailability and/or iron transfer to the fetus is impaired in overweight/obese (OW) pregnant women with adiposity-related inflammation, compared with normal-weight (NW) pregnant women. Methods In this prospective study, we followed NW (n = 43) and OW (n = 40) pregnant women who were receiving iron supplements from the 14th week of gestation to term and followed their infants to age 6 mo. We administered 57Fe and 58Fe in test meals mid-second and mid-third trimester, and measured tracer kinetics throughout pregnancy and infancy. Results In total, 38 NW and 36 OW women completed the study to pregnancy week 36, whereas 30 NW and 27 OW mother–infant pairs completed the study to 6 mo postpartum. Both groups had comparable iron status, hemoglobin, and serum hepcidin throughout pregnancy. Compared with the NW, the OW pregnant women had 1) 43% lower fractional iron absorption (FIA) in the third trimester (P = 0.033) with median [IQR] FIA of 23.9% [11.4%–35.7%] and 13.5% [10.8%–19.5%], respectively; and 2) 17% lower maternal–fetal iron transfer from the first tracer (P = 0.051) with median [IQR] maternal–fetal iron transfer of 4.8% [4.2%–5.4%] and 4.0% [3.6%–4.6%], respectively. Compared with the infants born to NW women, infants born to OW women had lower body iron stores (BIS) with median [IQR] 7.7 [6.3–8.8] and 6.6 [4.6–9.2] mg/kg body weight at age 6 mo, respectively (P = 0.024). Prepregnancy BMI was a negative predictor of maternal–fetal iron transfer (β = −0.339, SE = 0.144, P = 0.025) and infant BIS (β = −0.237, SE = 0.026, P = 0.001). Conclusions Compared with NW, OW pregnant women failed to upregulate iron absorption in late pregnancy, transferred less iron to their fetus, and their infants had lower BIS. These impairments were associated with inflammation independently of serum hepcidin

Why high school students refuse go to school? School attendance analysis, reasons, and school fears in a sample of Spanish high school students

El absentismo y el rechazo escolar son problemas de reconocimiento socio-educativo y motivo de estudio en las últimas décadas (Kearney y Silverman, 1996; Kearney, Lemos y Silverman, 2004; Kearney, Chapman y Cook, 2005; Fremont, 2003; Wimmer, 2008; Broc, 2010; Casoli-Reardom, Rappaport, y Reifeld, 2012; Carrera y Larrañaga, 2014). Desde los centros educativos de Secundaria y Bachiller se detectan las ausencias de alumnos y los servicios de orientación acusan la falta de recursos y competencias para atender a los alumnos/as que se sienten mal en el centro y que les agobia permanecer en el instituto. ¿Cómo se reparte el absentismo justificado de estos alumnos?, ¿Qué les ocurre para no querer ir a clase?, ¿De qué tienen miedo? Todas estas circunstancias son las que dan origen a este proyecto con el objetivo de describir el absentismo justificado, analizando las respuestas que da el alumnado al rechazo para acudir al centro y los miedos escolares más frecuentes en una muestra (N=405) de alumnos de ESO y Bachiller de Aragón, España. Se pretende animar a la sensibilización con esta problemática y a la puesta en marcha de medidas para la detección y prevención del rechazo escolar y absentismo justificado. Los resultados muestran mayor frecuencia significativa (p=.000) de absentismo en cursos superiores (M=16,97) que en inferiores (M=15,41) y los nervios generados por un examen (43,3%) o sensación de nerviosismo sin identificar causa explicita (27,2%), son las explicaciones más frecuentes de rechazo. Además, los resultados muestran mayor intensidad de miedos significativa (p=.001) en el sexo femenino (M=49,64) que masculino (M=39,81) y en el primer ciclo de secundaria (M=50,72) que en superiores (M=40,84).School attendance and school refusal are recognition socio-educational problems and they have been studied in recent decades. (Kearney & Silverman, 1996; Kearney, Lemos & Silverman, 2004; Kearney, Chapman & Cook, 2005a; Fremont, 2003; Wimmer, 2008b; Broc, 2010; Casoli-Reardom, Rappaport & Reifeld, 2012; Carrera & Larrañaga, 2014). In high schools student absences are detected, shool counseling services blame the lack of resources and skills which don not meet the demands of the students who feel bad and stress them to stay in school. How justified absenteeism distributed?, Why do they refuse going to school?, What are they afraid of? All these circumstances are those that set up and arise this project and the aim is to describe the justified absenteeism, analyzing the responses given by the students of rejection to go to school and the most frequent school fears in a sample (N=405) of high school students in Aragon, Spain. The intention is awareness of this issue, and the implementation of measures to detect and prevent school refusal and justified absenteeism. The results show a significant higher frequency of absenteeism (p=.000) at higher levels of secondary school (M=16, 97) than lower ones (M=15,41) and the nerves generated by a test (43,3%) or feeling anxious by unidentified cause (27,2%) are the more frequent reasons to reject the school attendance. In addition, the results show greater intensity of fear in women (p=.001) (M=49,64) than men (M=39,81) and junior secondary (M=50,72) than higher levels (M=40,84)

Pediatr Nephrol

BACKGROUND: Hemolytic uremic syndrome due to Shiga toxin-producing E. coli (STEC-HUS) is the main cause of acute kidney injury in young children. Most fully recover kidney function; however, some develop long-term sequelae. We aimed to determine whether kidney injury 1 year after HUS onset is associated with long-term kidney outcome in pediatric STEC-HUS. METHODS: A retrospective population-based study of children /= 1 signs of kidney injury. Data from 81 patients were collected after median follow-up of 8.7 (IQR 3.5-12.7) years. At last follow-up, 42 (44% of survivors) had >/= 1 signs of kidney injury including decreased estimated glomerular filtration rate (eGFR) < 90 mL/min/1.73 m(2) (n = 30), proteinuria (n = 17), or hypertension (n = 5). Among 42 patients with kidney injuries at 1-year follow-up, only 22 (52%) still had kidney disease at last follow-up. Conversely, of 33 patients without kidney injury at 1-year and available long-term outcome data, 11 (33%) had proteinuria or decreased GFR at last follow-up. There was no statistically significant association between kidney injury at 1 year and long-term kidney outcome. CONCLUSIONS: Since kidney sequelae may appear at variable time intervals after acute HUS, all patients need lifelong follow-up to detect early signs of chronic kidney disease and propose measures to slow progression